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Plasma & Blood Protein Binding Assay


  • Compounds may bind to plasma proteins so only a small fraction of the drug is free in the plasma
  • Rapid equilibrium dialysis
  • Cross-species plasma protein binding
  • Results reported as % bound and fraction unbound (fu)


Cell Culture Media Binding Assays


  • Compounds may bind to serum proteins in cell culture media so that only a small fraction of the drug is actually free in the media
  • Rapid equilibrium dialysis
  • A diverse selection of media available
  • Results reported as % bound and fraction unbound (fu)


Brain Tissue Binding Assays


  • Compounds may bind to brain proteins and lipids so only a small fraction of the drug is free in the plasma
  • Different to plasma protein binding as plasma has twice as much protein and brain has 20-fold more lipids
  • Rapid equilibrium dialysis method
  • Cross-species brain tissue binding
  • Results reported as % bound and fraction unbound (fu)

 

Tissue Binding Assays


  • Compounds may bind to tissue proteins and lipids so only a small fraction of the drug is free in the plasma
  • Rapid equilibrium dialysis method
  • A wide range of tissues and organs available
  • Cross-species tissue binding
  • Results reported as % bound and fraction unbound (fu)
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