RESPIRATORY RESEARCH
Pharmidex provides unique solutions and extensive experience, to support the pre-clinical progression of candidate therapeutics for target areas of unmet medical need within the respiratory disease area, such as asthma, chronic obstructive pulmonary disease (COPD), chronic cough and pulmonary infection.
Experts in providing translatable respiratory disease models. We combine our specialist knowledge, across different disciplines, to provide PK, PD, target engagement and efficacy information for drugs to progress through to clinical development.
Respiratory diseases are increasing in prevalence around the globe and affect millions of people annually.
Respiratory Services
Key Validated Services
- Acute lung injury (endotoxin-induced)
- Airway function
- ARDS
- Allergic rhinitis (OVA-induced)
- Asthma (steroid-sensitive and insensitive; – HDM, OVA or Alternaria-induced)
- Asthma exacerbations (HDM or OVA and infection-induced)
- Bronchospasm (Histamine or cholinergic induction)
- COPD (ozone induced)
- Cough (citric acid or capsaicin induced)
- Chronic cough (citric acid induced in models of asthma/IPF or with histamine or ATP)
- Pulmonary fibrosis (bleomycin-induced)
- Pulmonary infection (Influenza A and respiratory syncytial virus)
- In vitro assays (Isolated animal and human airways, animal and human inflammatory cells, plaque assays)
Respiratory Disease
Our Expertise
The company has over 22 years experience in the field of offering translatable inflammatory disease models to the pharma/biotech industry.
We have a variety of robust and fully validated models for respiratory disease such as asthma, COPD, allergic rhinitis, IPF and lung infection.
Key Features
- We provide a comprehensive research service, including pharmacodynamic assays and translatable respiratory disease models
Cytokines (Luminex)
Unlock insights from diverse sources like plasma, bronchoalveolar lavage fluid, urine, and tissue supernatant with our comprehensive matrix evaluation services.
Gain a deeper understanding of your samples for enhanced research outcomes.
MOUSE | MOUSE | RAT | HUMAN | HUMAN |
---|---|---|---|---|
CCL2/MCP1 | CXCL12 & 13 | CXCL1/KC | CCL2/MCP1 | CXCL12 & 13 |
CCL3/MIP-1alpha | Cystatin C | CXCL2/MIP-2 | CCL3/MIP-1alpha | Cystatin C |
CCL4/MIP1beta | G-CSF & GM-CSF | CXCL3 | CCL4/MIP1beta | G-CSF & GM-CSF |
CCL5/RANTES | ICAM-1 | GM-CSF | CCL5/RANTES | ICAM-1 |
CCL7/MCP-2 | IFNgamma | ICAM-1 | CCL7/MCP-3 | IFNgamma |
CCL8/MCP-2 | IL-1alpha & beta | IFNgamma | CCL8/MCP-2 | IL-1alpha & beta |
CCL11/Eotaxin | IL-(2, 3, 4, 5, 6, 7, 10, 12p70, 13, 17A, 25, 33) | IL-1alpha & beta | CCL11/Eotaxin | IL-(2, 3, 4, 5, 6, 7, 8/CXCL8, 10, 12p70, 13, 17A, 25, 33) |
CCL12/MCP-5 | MMP-(2, 3, 8) | IL-(2, 3, 4, 6, 10, 13, 18) | CCL19/MIP-3beta | MMP-(2, 3, 8) |
CCL19/MIP-3beta | SP-D | TIMP-1 | CCL20 /MIP-3alpha | SP-D |
CCL20 /MIP-3alpha | TIM-1/KIM-1 | TNFalpha | CXCL1/KC | TIM-1/KIM-1 |
CXCL1/KC | TNFalpha | VEGF | CXCL2/MIP-2 | TNFalpha |
CXCL2/MIP-2 | VEGF | CXCL10/IP-10 | TSLP | |
CXCL10/IP-10 |
Up to 20-plex, designed to your specification.
If you cannot see what you want in the lists, please enquire.