At Pharmidex, we understand the critical role of general toxicology studies in drug development. We provide tailored support for small molecules and biologics, serving as an integral extension of your team. Our services cover general toxicology studies for discovery or development programs, with or without GxP regulatory compliance. We offer a range of study types and tailored protocols to meet your research goals.

Our HO, MHRA, OLAW and AAALAC accredited toxicology department will help you with your preclinical and other early-stage product development needs to assure product safety and regulatory compliance.

Areas of Expertise

Pharmidex will design and implement standard and customised bespoke preclinical discovery or regulatory toxicology studies in our HO, MHRA, OLAW and AAALAC accredited in vivo toxicology facility.

Key Features

• A complete range of administration routes
• Clinical pathology sample analyses
• Discovery toxicology: tolerability and acute toxicity (MTD, DRF)
• Histopathology processing and support 
• Regulatory toxicology: OECD-compliant GLP toxicity studies
  

Routes of Administration

• In diet or drinking water 
• Intracranial
• Intramuscular
• Intranasal 
• Intraperitoneal 
• Intravaginal 
• Intravenous
• Medical devices or surgical implantations
• Oral gavage
• Rectal
• Subcutaneous
• Topical application (skin/ocular/buccal) 
• Via i.v./s.c./i.p. implanted cannula
• Via s.c./i.p. implanted osmotic minipump
  

Applications

• Carcinogenicity Testing 
• Discovery toxicology 
• Efficacy and safety assessments
• Medical device evaluation
• Regulatory toxicology
• Single dose to repeat dose 90+ day studies
• Toxicokinetic assessments
  

Species

• Rodents
• Rabbits

Supporting Capabilities

• Analytical chemistry
• Anatomic pathology 
• Bioanalysis
• Biodistribution
• Clinical Pathology
• Cytokine and biomarker analysis
  
• Dose formulation analysis
• Histopathology
  
• Immunohistochemistry 
• Necropsy