At Pharmidex, we understand the critical role of general toxicology studies in drug development. We provide tailored support for small molecules and biologics, serving as an integral extension of your team. Our services cover general toxicology studies for discovery or development programs, with or without GxP regulatory compliance. We offer a range of study types and tailored protocols to meet your research goals.

Our HO, MHRA, OLAW and AAALAC accredited toxicology department will help you with your preclinical and other early-stage product development needs to assure product safety and regulatory compliance.

Areas of Expertise

Pharmidex will design and implement standard and customised bespoke preclinical discovery or regulatory toxicology studies in our HO, MHRA, OLAW and AAALAC accredited in vivo toxicology facility.

Key Features

• Discovery toxicology: tolerability and acute toxicity (MTD, DRF)
• Regulatory toxicology: OECD-compliant GLP toxicity studies
• A complete range of administration routes
• Clinical pathology sample analyses
• Histopathology processing and support 
  

Routes of Administration

• In diet or drinking water 
• Oral gavage
• Rectal
• Intravaginal 
• Intravenous
• Subcutaneous
• Intraperitoneal 
• Intramuscular
• Intracranial 
• Intranasal 
• Topical application (skin/ocular/buccal) 
• Via i.v./s.c./i.p. implanted cannula
• Via s.c./i.p. implanted osmotic minipump
• Medical devices or surgical implantations
  

Applications

• Discovery toxicology 
• Regulatory toxicology
• Toxicokinetic assessments
• Efficacy and safety assessments
• Medical device evaluation
• Single dose to repeat dose 90+ day studies
• Carcinogenicity Testing 

Species

• Rodent

Supporting Capabilities

• Analytical chemistry 
• Bioanalysis
• Biodistribution
• Dose formulation analysis
• Anatomic pathology
• Cytokine and biomarker analysis
• Clinical pathology
• Immunohistochemistry 
•  Necropsy
•  Clinical pathology
•  Histopathology