At Pharmidex, we understand the critical role of general toxicology studies in drug development. We provide tailored support for small molecules and biologics, serving as an integral extension of your team. Our services cover general toxicology studies for discovery or development programs, with or without GxP regulatory compliance. We seamlessly integrate safety pharmacology protocols into these studies, offering a range of study types to meet your research goals.



Our MHRA and OLAW and AAALAC accredited toxicology department will help you with your preclinical and other early-stage product development needs to assure product safety and regulatory compliance.

Areas of Expertise

Pharmidex will design and implement standard and customised bespoke preclinical discovery or regulatory toxicology studies in our HO, MHRA, OLAW and AAALAC accredited in vivo toxicology facility.

Key Features

• Discovery toxicology: tolerability and acute toxicity (MTD, DRF)
• Regulatory toxicology: OECD-compliant GLP toxicity studies
• A complete range of administration routes
• Clinical pathology sample analyses
• Histopathology processing and support 
  

Routes of Administration

• In diet or drinking water 
• Oral gavage
• Rectal
• Intravaginal 
• Intravenous
• Subcutaneous
• Intraperitoneal 
• Intramuscular
• Intracranial 
• Intranasal 
• Topical application (skin/ocular/buccal) 
• Via i.v./s.c./i.p. implanted cannula
• Via s.c./i.p. implanted osmotic minipump
• Subcutaneous or orthotopical surgical minimally invasive implantation of biomaterials or medical implants (including diagnostic implantable devices) for evaluation of local/systemic toxic effects
  

Applications

• General discovery toxicology 
• Regulatory GLP toxicology
• Single dose studies (e.g. MTD)
• Repeat dose studies (e.g. DRF)
•  Toxicokinetic studies
•  Necropsy
•  Clinical pathology
•  Histopathology
  

Species

• Rodent

Supporting Capabilities

• Analytical chemistry 
• Bioanalysis
• Biodistribution
• Dose formulation analysis
• Anatomic pathology
• Cytokine and biomarker analysis
• Clinical pathology
• Immunohistochemistry