person holding rod

Preclinical

Expert preclinical support, from discovery to data.

Our services

Pharmidex delivers comprehensive, regulation-ready clinical services, from early-stage in vivo studies to advanced pharmacological research, designed to accelerate your drug development programmes.

Histology

Tissue processing, staining, and morphological analysis for preclinical and regulatory studies

Epithelial Tissues: Stratified Squamous Epithelium
Epithelial Tissues: Stratified Squamous Epithelium
Inflammation

In vivo and in vitro models to characterise inflammatory pathways and evaluate therapeutic candidates

Computational modelling and predictive analytics to guide candidate selection and optimisation

In silico drug discovery
yellow and black abstract painting
yellow and black abstract painting
a group of three different structures on a black background
a group of three different structures on a black background
person using disposable syringe put specimen on blue and white glucose meter
person using disposable syringe put specimen on blue and white glucose meter
Medical device testing

Biocompatibility and performance evaluation supporting regulatory submissions for medical devices

a bathroom with a lot of writing on the wall
a bathroom with a lot of writing on the wall
Medicinal chemistry

Synthesis, structure–activity relationship studies, and lead optimisation across modalities

boxes are stacked on top of each other in a warehouse
boxes are stacked on top of each other in a warehouse
Pharmacokinetics

In vivo PK studies and data analysis to define absorption, distribution, metabolism, and excretion

person in white long sleeve shirt holding green and white labeled can
person in white long sleeve shirt holding green and white labeled can
Toxicology

GLP and non-GLP safety studies designed to meet regulatory requirements and de-risk candidates

silver ring on white box
silver ring on white box
Vivarium facility

Purpose-built, accredited animal housing supporting a broad range of in vivo study designs

Maximise your probability of success. Our preclinical teams deliver regulatory-compliant, high-quality data efficiently, helping you make confident go/no-go decisions and advance promising candidates faster.

8

specialisms

GLP

and Non-GLP

Histology

Pharmidex's fully equipped histotechnology facility offers precise traceability from sample to slide, with calibrated semi-automated microtomes, automatic tissue processors and advanced microscopy systems. We process a broad range of sample types, including calcified tissues, supporting research across dermatology, respiratory, toxicology, oncology and CNS fields.

Inflammation

Pharmidex provides high-quality contract research services across gastrointestinal disease models, including ulcerative colitis, Crohn's disease and intestinal fibrosis, combining PK, PD, target engagement and efficacy expertise to progress candidate therapeutics from hit identification through to clinical evaluation.

In silico drug discovery

Pharmidex offers specialist in silico drug discovery services, from target identification and pathway analysis to molecular docking and ADMET prediction, combining cutting-edge computational biology, AI-driven design and gold-standard software to accelerate your drug discovery programme.

Medical device testing

Supporting medical device innovation through preclinical efficacy, safety and regulatory testing trusted by the life sciences sector worldwide.

Medicinal chemistry

Pharmidex offers comprehensive drug discovery chemistry services, from hit-to-lead through lead optimisation, collaborating closely with clients to design focused libraries, accelerate IND submissions and deliver high-quality target compounds efficiently.

Pharmacokinetics

Pharmidex offers high-quality, tailored pharmacokinetic services from state-of-the-art facilities in Hertfordshire, UK, providing fully integrated in vivo, bioanalysis and PK parameter determination to support every stage of your drug discovery programme.

Toxicology

At Pharmidex, we understand the critical role of general toxicology studies in drug development. We provide tailored support for small molecules and biologics, serving as an integral extension of your team. Our services cover general toxicology studies for discovery or development programs, with or without GxP regulatory compliance. We offer a range of study types and tailored protocols to meet your research goals.

Our HO, MHRA, OLAW and AAALAC accredited toxicology department will help you with your preclinical and other early-stage product development needs to assure product safety and regulatory compliance.

Vivarium facility

Pharmidex manages and runs a dedicated, state-of-the-art, category 2 facility. This establishment is fully compliant to Home Office, Animals (Scientific Procedures) Act. Accredited for AAALAC International and GLP.

Our highly skilled and qualified animal care technicians, scientists, licence holders, named persons ensure all projects conducted at Pharmidex are centred around the principles of the 3Rs and animal welfare policy.

AWERB – making essential contributions to improving science, animal welfare and the 3R’s, providing ethical advice and support to licence applications.

Contact Us

Address

167-169 Great Portland Street, Fifth Floor, London, W1W 5PF

Contacts

Email: bd@pharmidex.com