TEXT

Pharmacokinetics

Hit-to-lead (100s compounds)

• Screening/Definitive rodent PK
• Tissue exposure assessment
• Discrete or Cassette dosing
• Molecular Dynamics analysis
  

Specialty PK & Disposition Pharmacology

Lead Optimization (10s compounds)

• Bile duct cannulated Rat definitive PK assessment
• Liver hiumanized chimeric mouse models (FRG, PXB)
• PK/PD; Rat Telemetry

Toxicology

Candidate Selection (1-2 compounds)

• Single dose assessment (MTD)
• Multiple dose assessment (DRF)
• 7 day / 14 day exploratory toxicology in rodents
• GLP Toxicology